Proteínas del dogma central

Las proteínas de la matriz mitocondrial que participan en los procesos de replicación, transcripción y traducción específicamente mitocondriales se exponen en la siguiente tabla, así como otros elementos no proteicos de interés.

 

Ha sido encontrada en humano y es codificada por un gen nuclear
Ha sido encontrada en humano y es codificada por un gen mitocondrial
No ha sido encontrada en humano y es codificada por un gen nuclear

 

Gen / Proteína  Función Símbolo Enzima / Complejo

Número de Acceso GDB Posición  Citogenetica en humano / Especie 
DNA polymerase gammamtDNA replicationPOLGDNA polymerase gamma 15q24-q26
Exonuclease G      
Maturase enzimas     
amino acyl-tRNA synthetases     
nuclear RNA component required for processing     
Ribosomal protein S-5     
"Ribosomal proteins, as many as 85 different proteins"     
 Mitochondrial DNA Replication/ transcriptionMT7SDNA7S DNAG00-118-896MTH5721-16104
 Attachment site of mitochondrial genome to inner membraneMTATTMembrane Attachment Site

Inner membrane

G00-118-899MTH15925-499
 Conserved Sequence Block I in D-loop regionMTCSB1Conserved Sequence Block IG00-118-903MTL235-213
 Conserved Sequence Block II in D-loop regionMTCSB2Conserved Sequence Block IIG00-118-904MTL315-299
 Conserved Sequence Block III in D-loop regionMTCSB3Conserved Sequence Block IIIG00-118-905MTL363-346
 Mitochondrial genome replicationMTHPRReplication PrimerG00-118-907MTL321-317
 Mitochondrial H-strand transcription/replicationMTHSP1Major H Strand PromoterG00-118-908MTH545-567
 Mitochondrial H-strand transcription/replicationMTHSP2Minor H Strand PromoterG00-118-909MTH645-645
 Mitochondrial L-strand transcription/replicationMTLSPL Strand PromoterG00-118-910MTL445-392
 Mitochondrial L-strand origin of replicationMTOLRLight strand origin of replicationG00-118-919MTL5805-5729
 Mitochondrial protein synthesis/mitochondrial ribosomesMTRNR112S rRNAG00-118-920MTH648-1601
 Mitochondrial protein synthesis/mitochondrial ribosomesMTRNR216S rRNAG00-118-921MTH1671-3229
  MTRNR35S-like sequenceG00-118-922MTL3229-3206
 Mitochondrial protein synthesisMTTAtRNA alanineG00-118-923MTL5655-5587
 mitochondrial transcriptionMTTAStermination associated sequenceG00-118-924MTL16172-16157
 Mitochondrial protein synthesisMTTDtRNA aspartic acidG00-118-925MTH7518-7585
 Mitochondrial protein synthesisMTTEtRNA glutamic acidG00-118-926MTL14742-14149
 Mitochondrial genome transcriptionMTTERTranscription terminatorG00-118-927MTH3237-3249
 Mitochondrial protein synthesisMTTFtRNA phenylalanineG00-118-928MTH577-647
 Mitochondrial genome transcriptionMTTFHmitochondrial transcription factor binding site HG00-118-929MTH523-550
 Mitochondrial genome transcriptionMTTFLmitochondrial transcription factor binding site LG00-118-930MTL445-418
 Mitochondrial genome transcriptionMTTFXmitochondrial transcription factor binding site XG00-118-931MTL260-233
 Mitochondrial genome transcriptionMTTFYmitochondrial transcription factor binding site YG00-118-932MTL303-276
 Mitochondrial protein synthesisMTTGtRNA glycineG00-118-933MTH9991-10058
 Mitochondrial protein synthesisMTTHtRNA histidineG00-118-934MTH12138-12206
 Mitochondrial protein synthesisMTTItRNA isoleucineG00-118-935MTH4263-4331
 Mitochondrial protein synthesisMTTKtRNA lysineG00-118-936MTH8295-8364
 Mitochondrial protein synthesisMTTL1tRNA leucine 1 (UUA/G)G00-118-937MTH3230-3304
 Mitochondrial protein synthesisMTTL2tRNA leucine 2 (CUN)G00-118-938MTH12266-12336
 Mitochondrial protein synthesisMTTMtRNA methionineG00-118-939MTH4402-4469
 Mitochondrial protein synthesisMTTNtRNA asparagineG00-118-940MTL5729-5657
 Mitochondrial protein synthesisMTTPtRNA prolineG00-118-941MTL16023-15955
 Mitochondrial protein synthesisMTTQtRNA glutamineG00-118-942MTL4400-4329
 Mitochondrial protein synthesisMTTRtRNA arginineG00-118-943MTH10405-10469
 Mitochondrial protein synthesisMTTS1tRNA serine 1 (UCN)G00-118-944MTL7516-7445
 Mitochondrial protein synthesisMTTS2tRNA serine 2 (AGU/C)G00-118-945MTH12207-12265
 Mitochondrial protein synthesisMTTTtRNA threonineG00-118-946MTH15888-15953
 Mitochondrial protein synthesisMTTVtRNA valineG00-118-947MTH1602-1670
 Mitochondrial protein synthesisMTTWtRNA tryptophanG00-118-948MTH5512-5576
 Mitochondrial protein synthesisMTTYtRNA tyrosineG00-118-949MTL5891-5826
 Mitochondrial protein synthesisMTTCtRNA cysteineG00-138-133MTL5826-5761
 Mitochondrial genome replicationMTOHRHeavy Strand origin of replicationG00-118-918MTH110-441
 Mitochondrial genome transcriptionMTTFHMitochondrial Transcription Factor Binding Site HG00-118-929MTH523-550
 Mitochondrial genome transcriptionMTHSP1Major H-strand promoterG00-118-908MTH545-567
Mitochondrial Transcription Factor A (TCF6L2)Mitochondrial DNA TranscriptionTCF6L2Mitochondrial Transcription Factor AG00-127-55510q21
Single-stranded DNA-binding ProteinMitochondrial DNA ReplicationSSBPSingle-stranded DNA-binding ProteinG00-386-1907q34
Endonuclease GRNA maturation or possibly DNA repairENDOGEndonuclease GG00-386-1919q34.1

El visitante puede encontrar información adicional de cada gen y proteína en MitoDat database en http://www-lecb.ncifcrf.gov/mitoDat, MitoDat database recopila la información sobre proteínas mitocondriales actualizada por S. Zullo, Ph. D.  y donde puede obtener otros valiosos datos incluidas las referencias bibliográficas de cada proteína.

La anterior tabla será traducida en etapas sucesivas al español, y será completada con otras aportaciones.

 

cadena H

pseudogenes mitocondriales

genes de tRNAs

genes de mRNAs

cadena transportadora

cadena L

nomenclatura aminoácidos

código estandar

código mitocondrial

genes de rRNAs

secuencias de DNA

expresión del mitDNA

mitobase proteica

el mitomapa

oligocalculator

herramientas de cálculo

terapia génica y ética

links

la mitocondria humana

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